From drug repositioning to target repositioning: prediction of therapeutic targets using genetically perturbed transcriptomic signatures.

ABSTRACT:

Motivation

A critical element of drug development is the identification of therapeutic targets for diseases. However, the depletion of therapeutic targets is a serious problem.

Results

In this study, we propose the novel concept of target repositioning, an extension of the concept of drug repositioning, to predict new therapeutic targets for various diseases. Predictions were performed by a trans-disease analysis which integrated genetically perturbed transcriptomic signatures (knockdown of 4345 genes and overexpression of 3114 genes) and disease-specific gene transcriptomic signatures of 79 diseases. The trans-disease method, which takes into account similarities among diseases, enabled us to distinguish the inhibitory from activatory targets and to predict the therapeutic

SUBMITTER: Namba S 

PROVIDER: S-EPMC9235496 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature