MOJITOO: a fast and universal method for integration of multimodal single-cell data.

ABSTRACT:

Motivation

The advent of multi-modal single-cell sequencing techniques have shed new light on molecular mechanisms by simultaneously inspecting transcriptomes, epigenomes and proteomes of the same cell. However, to date, the existing computational approaches for integration of multimodal single-cell data are either computationally expensive, require the delineation of parameters or can only be applied to particular modalities.

Results

Here we present a single-cell multi-modal integration method, named Multi-mOdal Joint IntegraTion of cOmpOnents (MOJITOO). MOJITOO uses canonical correlation analysis for a fast and parameter free detection of a shared representation of cells from multimodal single-cell data. Moreover, estimated canonical components can be used for interpretati

SUBMITTER: Cheng M 

PROVIDER: S-EPMC9235504 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature