Epigenetic DNA Methylation Signatures Associated With the Severity of Paget's Disease of Bone.

ABSTRACT: Background: Paget's disease of bone (PDB) is characterized by focal areas of dysregulated bone turnover resulting in increased bone loss and abnormal bone formation with variable severity. PDB has a complex etiology and both genetics and environmental factors have been implicated. A recent study has identified many differentially methylated loci in PDB compared to healthy subjects. However, associations between DNA methylation profiles and disease severity of PDB have not been investigated. Objectives: To investigate the association between DNA methylation signals and PDB severity. Methods: Using 232 well-characterized PDB subjects from the PRISM trial, a disease severity score was devised based on the clinical features of PDB. DNA methylation profiling was performed u

SUBMITTER: Diboun I 

PROVIDER: S-EPMC9235511 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature