Dynamic interplay between life events and course of psychotic disorders: 10-year longitudinal study following first admission.

ABSTRACT:

Background

Life events (LEs) are a risk factor for first onset and relapse of psychotic disorders. However, the impact of LEs on specific symptoms - namely reality distortion, disorganization, negative symptoms, depression, and mania - remains unclear. Moreover, the differential effects of negative v. positive LEs are poorly understood.

Methods

The present study utilizes an epidemiologic cohort of patients (N = 428) ascertained at first-admission for psychosis and followed for a decade thereafter. Symptoms were assessed at 6-, 24-, 48-, and 120-month follow-ups.

Results

We examined symptom change within-person and found that negative events in the previous 6 months predicted an increase in reality distortion (β = 0.07), disorganized (β = 0.

SUBMITTER: Donaldson KR 

PROVIDER: S-EPMC9235544 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature