Monitoring of inflammation using novel biosensor mouse model reveals tissue- and sex-specific responses to Western diet.

ABSTRACT: Obesity is an epidemic, and it is characterized by a state of low-grade systemic inflammation. A key component of inflammation is the activation of inflammasomes, multiprotein complexes that form in response to danger signals and that lead to activation of caspase-1. Previous studies have found that a Westernized diet induces activation of inflammasomes and production of inflammatory cytokines. Gut microbiota metabolites, including the short-chain fatty acid butyrate, have received increased attention as underlying some obesogenic features, but the mechanisms of action by which butyrate influences inflammation in obesity remain unclear. We engineered a caspase-1 reporter mouse model to measure spatiotemporal dynamics of inflammation in obese mice. Concurrent with increased capsase-1 activa

SUBMITTER: Talley S 

PROVIDER: S-EPMC9235879 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature