P53-Related Anticancer Activities of Drimia calcarata Bulb Extracts Against Lung Cancer.

ABSTRACT: Current lung cancer treatment strategies are ineffective, and lung cancer cases continue to soar; thus, novel anticancer drugs and targets are needed, and medicinal plants are promising to offer better alternatives. This study was aimed at analysing two p53 splice variants during the potential anticancer activities of Drimia calcarata (Dc) methanol and water extracts against different human lung cancer cell lines of varying p53 mutation status, and these included mutant H1573 and mutant H1437 and p53-wild type (A549) cells. The anticancer activities of the Dc extracts were assessed by establishing the cytotoxic effect and the apoptosis-inducing capacity of these extracts, using the MTT assay and Annexin V analysis, respectively, with the latter con

SUBMITTER: Laka K 

PROVIDER: S-EPMC9235921 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature