Maternal antibiotics disrupt microbiome, behavior, and temperature regulation in unexposed infant mice.
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ABSTRACT:
SUBMITTER: Harshaw C
PROVIDER: S-EPMC9236156 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Maternal antibiotics disrupt microbiome, behavior, and temperature regulation in unexposed infant mice.
Harshaw Christopher C Kojima Sayuri S Wellman Cara L CL Demas Gregory E GE Morrow Ardythe L AL Taft Diana Hazard DH Kenkel William M WM Leffel Joseph K JK Alberts Jeffrey R JR
Developmental psychobiology 20220901 6
Maternal antibiotic (ABx) exposure can significantly perturb the transfer of microbiota from mother to offspring, resulting in dysbiosis of potential relevance to neurodevelopmental disorders such as autism spectrum disorder (ASD). Studies in rodent models have found long-term neurobehavioral effects in offspring of ABx-treated dams, but ASD-relevant behavior during the early preweaning period has thus far been neglected. Here, we exposed C57BL/6J mouse dams to ABx (5 mg/ml neomycin, 1.25 μg/ml ...[more]
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