Ontology highlight
ABSTRACT:
SUBMITTER: Hochuli JE
PROVIDER: S-EPMC9236207 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
ACS pharmacology & translational science 20220622 7
The COVID-19 pandemic has had enormous health, economic, and social consequences. Vaccines have been successful in reducing rates of infection and hospitalization, but there is still a need for acute treatment of the disease. We investigate whether compounds that bind the human angiotensin-converting enzyme 2 (ACE2) protein can decrease SARS-CoV-2 replication without impacting ACE2's natural enzymatic function. Initial screening of a diversity library resulted in hit compounds active in an ACE2- ...[more]