The Role of Fecal Microbiota in Liver Toxicity Induced by Perfluorooctane Sulfonate in Male and Female Mice.

ABSTRACT:

Background

Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant that can cause hepatotoxicity. The underlying toxicological mechanism remains to be investigated. Given the critical role of fecal microbiota in liver function, it is possible that fecal microbiota may contribute to the liver toxicity induced by PFOS.

Objectives

We aimed to investigate the role of liver-fecal microbiota axis in modulating PFOS-induced liver injury in mice.

Methods

Male and female mice were exposed to PFOS or vehicle for 14 d. In this investigation, 16S rDNA sequencing and metabolomic profiling were performed to identify the perturbed fecal microbiota and altered metabolites with PFOS exposure. In addition, antibiotic treatment, fecal microbiota transplantation, and bacterial

SUBMITTER: Jiang L 

PROVIDER: S-EPMC9236209 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature