Clinical Burkholderia pseudomallei isolates from north Queensland carry diverse bimABm genes that are associated with central nervous system disease and are phylogenomically distinct from other Australian strains.

ABSTRACT:

Background

Burkholderia pseudomallei is an environmental gram-negative bacterium that causes the disease melioidosis and is endemic in many countries of the Asia-Pacific region. In Australia, the mortality rate remains high at approximately 10%, despite curative antibiotic treatment being available. The bacterium is almost exclusively found in the endemic region, which spans the tropical Northern Territory and North Queensland, with clusters occasionally present in more temperate climates. Despite being endemic to North Queensland, these infections remain understudied compared to those of the Northern Territory.

Methodology/principal findings

This study aimed to assess the prevalence of central nervous system (CNS) disease associated variant bimABm, identify circulating anti

SUBMITTER: Burnard D 

PROVIDER: S-EPMC9236262 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature