Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning.

ABSTRACT: A plethora of experimental studies have shown that long-term synaptic plasticity can be expressed pre- or postsynaptically depending on a range of factors such as developmental stage, synapse type, and activity patterns. The functional consequences of this diversity are not clear, although it is understood that whereas postsynaptic expression of plasticity predominantly affects synaptic response amplitude, presynaptic expression alters both synaptic response amplitude and short-term dynamics. In most models of neuronal learning, long-term synaptic plasticity is implemented as changes in connective weights. The consideration of long-term plasticity as a fixed change in amplitude corresponds more closely to post- than to presynaptic expression, which means theoretical outcomes based on this

SUBMITTER: Mizusaki BEP 

PROVIDER: S-EPMC9236267 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature