A timeseries analysis of the fracture callus extracellular matrix proteome during bone fracture healing.

ABSTRACT: While most bones fully self-heal, certain diseases require bone allograft to assist with fracture healing. Bone allografts offer promise as treatments for such fractures due to their osteogenic properties. However, current bone allografts made of decellularized bone extracellular matrix (ECM) have high failure rates, and thus grafts which improve fracture healing outcomes are needed. Understanding specific changes to the ECM proteome during normal fracture healing would enable the identification of key proteins that could be used enhance osteogenicity of bone allograft. Here, we performed a timeseries analysis of the fracture callus in mice to investigate proteomic and mineralization changes to the ECM at key stages of fracture healing. We found that changes to the ECM proteome largely coi

SUBMITTER: Erickson CB 

PROVIDER: S-EPMC9236279 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature