Cortico-cerebellar connectivity underlying motor control in chronic post-stroke individuals.

ABSTRACT: The robust, reciprocal anatomical connections between the cerebellum and contralateral sensorimotor cerebral hemisphere underscores the strong physiological interdependence between these two regions in relation to human behavior. Previous studies have shown that damage to sensorimotor cortex can result in a lasting reduction of cerebellar metabolism, the magnitude of which has been linked to poor rehabilitative outcomes. A better understanding of movement-related cerebellar physiology as well as cortico-cerebellar coherence (CCC) in the chronic, post-stroke state may be key to developing novel neuromodulatory techniques that promote upper limb motor rehabilitation. As a part of the first in-human phase-I trial investigating the effects of deep brain stimulation of the cerebellar dentate nu

SUBMITTER: Gopalakrishnan R 

PROVIDER: S-EPMC9236286 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature