Dataset Information

Neuromuscular electrical stimulation and protein during bed rest increases CD11b⁺ skeletal muscle macrophages but does not correspond to muscle size or insulin sensitivity.

ABSTRACT: With this cohort, we previously demonstrated preservation of thigh lean tissue with neuromuscular electrical stimulation combined with protein supplementation (NMES+PRO) treatment during bed rest in healthy older adults. Because macrophage polarization plays a significant role in the repair and maintenance of muscle size and insulin sensitivity, we hypothesized that muscle macrophages would be induced by NMES+PRO and would correspond to an increase in lean mass and an attenuated insulin resistance response altered by bed rest. Older adults (60-80 years old; body mass index < 30 kg/m²) underwent 5 days of bed rest and were randomized to either thrice daily treatment of NMES+PRO (n = 8) or CON (n = 8). Lean mass, insulin sensitivity, and markers of muscle macrophages

SUBMITTER: Reidy PT

PROVIDER: S-EPMC9236569 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Dataset Information

Neuromuscular electrical stimulation and protein during bed rest increases CD11b⁺ skeletal muscle macrophages but does not correspond to muscle size or insulin sensitivity.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Neuromuscular electrical stimulation and protein during bed rest increases CD11b+ skeletal muscle macrophages but does not correspond to muscle size or insulin sensitivity.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Neuromuscular electrical stimulation and protein during bed rest increases CD11b⁺ skeletal muscle macrophages but does not correspond to muscle size or insulin sensitivity.