Simulating domain architecture evolution.

ABSTRACT:

Motivation

Simulation is an essential technique for generating biomolecular data with a 'known' history for use in validating phylogenetic inference and other evolutionary methods. On longer time scales, simulation supports investigations of equilibrium behavior and provides a formal framework for testing competing evolutionary hypotheses. Twenty years of molecular evolution research have produced a rich repertoire of simulation methods. However, current models do not capture the stringent constraints acting on the domain insertions, duplications, and deletions by which multidomain architectures evolve. Although these processes have the potential to generate any combination of domains, only a tiny fraction of possible domain combinations are observed in nature. Modeling these strin

SUBMITTER: Cui X 

PROVIDER: S-EPMC9236583 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature