Associations of mismatch negativity with psychotic symptoms and functioning transdiagnostically across psychotic disorders.

ABSTRACT: Mismatch negativity (MMN) amplitude has been widely shown to be diminished in schizophrenia and, more recently, in other psychotic disorders. Although there is considerable evidence linking MMN reduction to cognitive and functional deficits in schizophrenia, there is little evidence of associations with specific psychotic symptoms. Further, it is unclear if MMN reductions relate to specific symptoms, cognitive, and functional deficits transdiagnostically across different psychotic disorders. The present study examines MMN amplitude in a large cohort of cases diagnosed with psychotic disorders including schizophrenia and schizoaffective disorder (N = 116); bipolar disorder and major depressive disorder (N = 75); and other psychotic disorders (N = 25), as well as individuals with no psychoti

SUBMITTER: Donaldson KR 

PROVIDER: S-EPMC9236595 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature