ApoA-I Infusion Therapies Following Acute Coronary Syndrome: Past, Present, and Future.

ABSTRACT:

Purpose of review

The elevated adverse cardiovascular event rate among patients with low high-density lipoprotein cholesterol (HDL-C) formed the basis for the hypothesis that elevating HDL-C would reduce those events. Attempts to raise endogenous HDL-C levels, however, have consistently failed to show improvements in cardiovascular outcomes. However, steady-state HDL-C concentration does not reflect the function of this complex family of particles. Indeed, HDL functions correlate only weakly with serum HDL-C concentration. Thus, the field has pivoted from simply raising the quantity of HDL-C to a focus on improving the putative anti-atherosclerotic functions of HDL particles. Such functions include the ability of HDL to promote the efflux of cholesterol from cholesterol-laden macro

SUBMITTER: Kalayci A 

PROVIDER: S-EPMC9236992 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature