Phenotypic decanalization driven by social determinants could explain variance patterns for glycemia in adult urban Argentinian population.

ABSTRACT: Type 2 diabetes, one of the major causes of death and disability worldwide, is characterized by problems in the homeostasis of blood glucose. Current preventive policies focus mainly on individual behaviors (diet, exercise, salt and alcohol consumption). Recent hypotheses state that the higher incidence of metabolic disease in some human populations may be related to phenotypic decanalization causing a heightened phenotypic variance in response to unusual or stressful environmental conditions, although the nature of these conditions is under debate. Our aim was to explore variability patterns of fasting blood glucose to test phenotypic decanalization as a possible explanation of heightened prevalence for type 2 diabetes in some groups and to detect variables associated with its variance us

SUBMITTER: Petino Zappala MA 

PROVIDER: S-EPMC9237041 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature