Automated Classification of Mild Cognitive Impairment by Machine Learning With Hippocampus-Related White Matter Network.

ABSTRACT:

Background

Detection of mild cognitive impairment (MCI) is essential to screen high risk of Alzheimer's disease (AD). However, subtle changes during MCI make it challenging to classify in machine learning. The previous pathological analysis pointed out that the hippocampus is the critical hub for the white matter (WM) network of MCI. Damage to the white matter pathways around the hippocampus is the main cause of memory decline in MCI. Therefore, it is vital to biologically extract features from the WM network driven by hippocampus-related regions to improve classification performance.

Methods

Our study proposes a method for feature extraction of the whole-brain WM network. First, 42 MCI and 54 normal control (NC) subjects were recruited using diffusion tensor imaging (DTI),

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC9237212 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature