Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder.

ABSTRACT:

Introduction

Sleep problems are prevalent among individuals with autism spectrum disorder (ASD), and a role has been attributed to melatonin in this multifactorial comorbidity.

Methods

A cross-sectional study was conducted on 41 autistic children and adolescents (9.9 ± 3.02) and 24 children and adolescents with a normal intellectual function (8.42 ± 2.43) were used as controls. Subjects were matched for sex, body mass index, and pubertal stage, and all were drug-naive. Circadian and sleep parameters were studied using an ambulatory circadian monitoring (ACM) device, and saliva samples were collected around the onset of sleep to determine dim light melatonin onset (DLMO).

Results

Prepubertal individuals with ASD presented later DLMO and an earlier decline in melatonin

SUBMITTER: Martinez-Cayuelas E 

PROVIDER: S-EPMC9237227 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature