Identification of Immune-Related Hub Genes in Thymoma: Defects in CD247 and Characteristics of Paraneoplastic Syndrome.

ABSTRACT: Background: Thymomas (Ts) and thymic carcinomas (TCs) are rare primary tumors of the mediastinum. Paraneoplastic syndrome (PNS) is an important feature of thymoma, which presents great challenges to clinicians. Methods: The present study uses the weighted gene co-expression network analysis (WGCNA) to identify possible immunologic mechanisms of thymoma. RNA sequencing data from thymoma samples were downloaded from the TCGA. Core genes were taken from the module that is closely related to the WHO's stage of classification. Enhanced analysis using the online database "Metascape" and an overall survival (OS) analysis were carried out via the Kaplan-Meier method. The hub genes were obtained from the protein-protein interaction (PPI) network. In addition, we jointly analyzed multi

SUBMITTER: Deng LF 

PROVIDER: S-EPMC9237438 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature