Integrated Bioinformatic Analysis of DNA Methylation and Immune Infiltration in Endometrial Cancer.

ABSTRACT:

Background

Endometrial cancer greatly threatens the health of female. Emerging evidences have demonstrated that DNA methylation and immune infiltration are involved in the occurrence and development of endometrial cancer. However, the mechanism and prognostic biomarkers of endometrial cancer are still unclear. In this study, we assess DNA methylation and immune infiltration via bioinformatic analysis.

Methods

The latest RNA-Seq, DNA methylation data, and clinical data related to endometrial cancer were downloaded from the UCSC Xena dataset. The methylation-driven genes were selected, and then the risk score was obtained using "MethylMix" and "corrplot" R packages. The connection between methylated genes and the expression of screened driven genes were explored using "survmin

SUBMITTER: Dai F 

PROVIDER: S-EPMC9237709 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature