Association of APOE Genotypes and Chronic Traumatic Encephalopathy.

ABSTRACT:

Importance

Repetitive head impact (RHI) exposure is the chief risk factor for chronic traumatic encephalopathy (CTE). However, the occurrence and severity of CTE varies widely among those with similar RHI exposure. Limited evidence suggests that the APOEε4 allele may confer risk for CTE, but previous studies were small with limited scope.

Objective

To test the association between APOE genotype and CTE neuropathology and related endophenotypes.

Design, setting, and participants

This cross-sectional genetic association study analyzed brain donors from February 2008 to August 2019 from the Veterans Affairs-Boston University-Concussion Legacy Foundation Brain Bank. All donors had exposure to RHI from contact sports or military service. All eligible donors were included. A

SUBMITTER: Atherton K 

PROVIDER: S-EPMC9237800 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature