Effects of antipsychotics on heart rate in treatment of schizophrenia: a systematic review and meta-analysis.

ABSTRACT:

Background

Antipsychotics are the treatment of choice in the therapy of schizophrenia. These drugs can be associated with changes in heart rate, but this question has never been examined systematically.

Objective

We aimed to analyse changes in heart rate during treatment with antipsychotics using the frequency of tachycardia and bradycardia events.

Design

For this systematic review and meta-analysis, we included all randomized controlled trials for the acute treatment of schizophrenia comparing antipsychotics head-to-head or with placebo.

Data sources and methods

We searched Embase, MEDLINE, PsycINFO, PubMed, BIOSIS, Cochrane Central Register of Controlled Trials (CENTRAL), WHO International Clinical Trials Registry Platform and ClinicalTrials.gov (last search

SUBMITTER: Huhn M 

PROVIDER: S-EPMC9237927 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature