Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology.

ABSTRACT: Tau is a predominantly neuronal, soluble and natively unfolded protein that can bind and stabilize microtubules in the central nervous system. Tau has been extensively studied over several decades, especially in the context of neurodegenerative diseases where it can aberrantly aggregate to form a spectrum of pathological inclusions. The presence of tau inclusions in the form of neurofibrillary tangles, neuropil threads and dystrophic neurites within senile plaques are essential and defining features of Alzheimer's disease. The current dogma favors the notion that tau is predominantly an axonal protein, and that in Alzheimer's disease there is a redistribution of tau towards the neuronal soma that is associated with the formation of pathological inclusions such as neurofibrillary tangles an

SUBMITTER: Paterno G 

PROVIDER: S-EPMC9237980 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature