Interaction of alginate with nano-hydroxyapatite-collagen using strontium provides suitable osteogenic platform.

ABSTRACT:

Background

Hydrogels based on organic/inorganic composites have been at the center of attention for the fabrication of engineered bone constructs. The establishment of a straightforward 3D microenvironment is critical to maintaining cell-to-cell interaction and cellular function, leading to appropriate regeneration. Ionic cross-linkers, Ca²⁺, Ba²⁺, and Sr²⁺, were used for the fabrication of Alginate-Nanohydroxyapatite-Collagen (Alg-nHA-Col) microspheres, and osteogenic properties of human osteoblasts were examined in in vitro and in vivo conditions after 21 days.

Results

Physicochemical properties of hydrogels illustrated that microspheres cross-linked with Sr²⁺ had reduced swelling, enhanced stability, and mechanical strength, as

SUBMITTER: Hassani A 

PROVIDER: S-EPMC9238039 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature