Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD⁺ salvage metabolic pathway.

ABSTRACT:

Background

Acute liver failure (ALF) patients are often accompanied by severe energy metabolism abnormalities and intestinal microecological imbalance. The intestinal mucosal barrier is severely damaged. Intestinal endotoxin can induce intestinal endotoxemia through the "Gut-Liver axis". More and more evidence shows that members of the gut microbiota, especially Fusobacterium nucleatum (F. nucleatum), are related to inflammatory bowel disease, but whether F. nucleatum is involved in the development of ALF and whether it affects the liver energy metabolism is unclear.

Methods

This study first detected the abundance of F. nucleatum and its effect on ALF disease, and explored whether F. nucleatum aggravated liver inflammation in vitro and in vivo.

Results

Our data showed

SUBMITTER: Cao P 

PROVIDER: S-EPMC9238040 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature