Investigating the characteristics of genes and variants associated with self-reported hearing difficulty in older adults in the UK Biobank.

ABSTRACT:

Background

Age-related hearing loss is a common, heterogeneous disease with a strong genetic component. More than 100 loci have been reported to be involved in human hearing impairment to date, but most of the genes underlying human adult-onset hearing loss remain unknown. Most genetic studies have focussed on very rare variants (such as family studies and patient cohort screens) or very common variants (genome-wide association studies). However, the contribution of variants present in the human population at intermediate frequencies is hard to quantify using these methods, and as a result, the landscape of variation associated with adult-onset hearing loss remains largely unknown.

Results

Here we present a study based on exome sequencing and self-reported hearing difficulty

SUBMITTER: Lewis MA 

PROVIDER: S-EPMC9238072 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature