Single nucleotide polymorphism analysis of pvmdr-1 in Plasmodium vivax isolated from military personnel of Republic of Korea in 2016 and 2017.

ABSTRACT:

Background

Malaria chemoprophylaxis using chloroquine (CQ) and primaquine (PQ) has been administered to resident soldiers in the 3rd Army of Republic of Korea (ROK) to prevent malaria infection since the year 1997. Due to mass chemoprophylaxis against malaria, concern exists about the occurrence of chloroquine resistance (CQR). This study aimed to investigate the single nucleotide polymorphisms (SNPs) of the Plasmodium vivax multi-drug resistance protein-1 (pvmdr-1) gene to monitor the risk of CQR.

Methods

SNPs of the pvmdr-1 gene were analysed in 73 soldiers of the 3^rd Army of ROK diagnosed with infection by P. vivax.

Results

Quintuple mutations (G698S, L845F, M908L, T958M, and F1076L) were detected in 73 soldiers. A newly identified non-synonymous mutatio

SUBMITTER: Bong JJ 

PROVIDER: S-EPMC9238087 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature