Sparse logistic regression revealed the associations between HBV PreS quasispecies and hepatocellular carcinoma.

ABSTRACT:

Background

Chronic infection with hepatitis B virus (HBV) has been proved highly associated with the development of hepatocellular carcinoma (HCC).

Aims

The purpose of the study is to investigate the association between HBV preS region quasispecies and HCC development, as well as to develop HCC diagnosis model using HBV preS region quasispecies.

Methods

A total of 104 chronic hepatitis B (CHB) patients and 117 HBV-related HCC patients were enrolled. HBV preS region was sequenced using next generation sequencing (NGS) and the nucleotide entropy was calculated for quasispecies evaluation. Sparse logistic regression (SLR) was used to predict HCC development and prediction performances were evaluated using receiver operating characteristic curves.

Results

Entropy o

SUBMITTER: Jia JA 

PROVIDER: S-EPMC9238101 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature