Contribution of tetrodotoxin-resistant persistent Na⁺ currents to the excitability of C-type dural afferent neurons in rats.

ABSTRACT:

Background

Growing evidence supports the important role of persistent sodium currents (I_NaP) in the neuronal excitability of various central neurons. However, the role of tetrodotoxin-resistant (TTX-R) Na⁺ channel-mediated I_NaP in the neuronal excitability of nociceptive neurons remains poorly understood.

Methods

We investigated the functional role of TTX-R I_NaP in the excitability of C-type nociceptive dural afferent neurons, which was identified using a fluorescent dye, 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchloride (DiI), and a whole-cell patch-clamp technique.

Results

TTX-R I_NaP were found in most DiI-positive neurons, but their density was proportional to neuronal size. Although the voltag

SUBMITTER: Nakamura M 

PROVIDER: S-EPMC9238149 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature