Emerging role of exosomes in cancer progression and tumor microenvironment remodeling.

ABSTRACT: Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability

SUBMITTER: Paskeh MDA 

PROVIDER: S-EPMC9238168 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature