The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus.

ABSTRACT:

Background

Previous research has linked elevated low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC) with diabetes mellitus (DM). The present study aims to estimate the RC-related DM risk beyond LDL-C, and to investigate the extent to which the association of RC and DM is mediated via insulin resistance and inflammation.

Methods

We enrolled 7308 individuals without previous history of DM into the present study from the China Health and Nutrition Survey. Fasting RC was calculated as total cholesterol minus LDL-C and high-density lipoprotein cholesterol. Subjects were divided into four groups according to their LDL-C (100 mg/dL) and RC (24 mg/dL) levels to evaluate the role of LDL-C vs. RC on DM. A logistic regression analysis was then employed to evaluate

SUBMITTER: Hu X 

PROVIDER: S-EPMC9238255 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature