The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice: a new factor in the host-microbiome interaction.

ABSTRACT:

Background

Colorectal cancer, one of the most common malignancies worldwide, is associated with a high mortality rate, mainly caused by metastasis. Comparative metagenome-wide association analyses of healthy individuals and cancer patients suggest a role for the human intestinal microbiota in tumor progression. However, the microbial molecules involved in host-microbe communication are largely unknown, with current studies mainly focusing on short-chain fatty acids and amino acid metabolites as potential mediators. Quorum sensing peptides are not yet considered in this context since their presence in vivo and their ability to affect host cells have not been reported so far.

Results

Here, we show that EntF*, a metabolite of the quorum sensing peptide EntF produced by Enteroco

SUBMITTER: Wynendaele E 

PROVIDER: S-EPMC9238271 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature