Comparison and optimization of sheep in vivo intervertebral disc injury model.

ABSTRACT:

Background

The current standard of care for intervertebral disc (IVD) herniation, surgical discectomy, does not repair annulus fibrosus (AF) defects, which is partly due to the lack of effective methods to do so and is why new repair strategies are widely investigated and tested preclinically. There is a need to develop a standardized IVD injury model in large animals to enable comparison and interpretation across preclinical study results. The purpose of this study was to compare in vivo IVD injury models in sheep to determine which annulus fibrosus (AF) defect type combined with partial nucleus pulposus (NP) removal would better mimic degenerative human spinal pathologies.

Methods

Six skeletally mature sheep were randomly assigned to one of the two observation perio

SUBMITTER: Constant C 

PROVIDER: S-EPMC9238284 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature