In vivo fluid transport in human intervertebral discs varies by spinal level and disc region.

ABSTRACT:

Background

The lumbar discs are large, dense tissues that are primarily avascular, and cells residing in the central region of the disc are up to 6-8 mm from the nearest blood vessel in adults. To maintain homeostasis, disc cells rely on nutrient transport between the discs and adjacent vertebrae. Thus, diminished transport has been proposed as a factor in age-related disc degeneration.

Methods

In this study, we used magnetic resonance imaging (MRI) to quantify diurnal changes in T2 relaxation time, an MRI biomarker related to disc hydration, to generate 3D models of disc fluid distribution and determine how diurnal changes in fluid varied by spinal level. We recruited 10 participants (five males/five females; age: 21-30 years; BMI: 19.1-29.0 kg/m²) and evaluated

SUBMITTER: Martin JT 

PROVIDER: S-EPMC9238288 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature