Association Between the Growth Hormone/Insulin-Like Growth Factor-1 Axis and Muscle Density in Children and Adolescents of Short Stature.

ABSTRACT:

Objective

To evaluate the association between the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis and muscle density in children and adolescents of short stature.

Methods

Participants were children and adolescents of short stature hospitalized in the Affiliated Hospital of Jining Medical University between January 2020 and June 2021. All participants had CT scan images available. We performed an analysis of the images to calculate the muscle density or skeletal muscle attenuation (SMA), skeletal muscle index (SMI), and fat mass index (FMI). Bioelectrical impedance analysis (BIA) was used to ensure that chest CT is a credible way of evaluating body composition.

Results

A total of 297 subjects were included with the mean age of 10.00 ± 3.42 years, mean hei

SUBMITTER: Yang G 

PROVIDER: S-EPMC9238351 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature