Causal Associations of Obesity With Achilles Tendinopathy: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Achilles tendinopathy (AT) is associated with severe pain and is the cause of dysfunction and disability that are associated with significant reduction in social and economic benefits. Several potential risk factors have been proposed to be responsible for AT development; however, the results of observational epidemiological studies remain controversial, presumably because the designs of these studies are subject to residual confounding and reverse causality. Mendelian randomization (MR) can infer the causality between exposure and disease outcomes using genetic variants as instrumental variables, and identification of the causal risk factors for AT is beneficial for early intervention. Thus, we employed the MR strategy to evaluate the causal associations between previou

SUBMITTER: He L 

PROVIDER: S-EPMC9238354 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature