Diastolic Dysfunction With Preserved Ejection Fraction After the Fontan Procedure.

ABSTRACT: Background Heart failure phenotyping in single-ventricle Fontan patients is challenging, particularly in patients with normal ejection fraction (EF). The objective of this study was to identify Fontan patients with abnormal diastolic function, who are high risk for heart failure with preserved ejection fraction (HFpEF), and characterize their cardiac mechanics, exercise function, and functional health status. Methods and Results Data were obtained from the Pediatric Heart Network Fontan Cross-sectional Study database. EF was considered abnormal if <50%. Diastolic function was defined as abnormal if the diastolic pressure:volume quotient (lateral E:e'/end-diastolic volume) was >90th percentile (≥0.26 mL^-1). Patients were divided into: controls=normal EF and diastolic function; sy

SUBMITTER: Chowdhury SM 

PROVIDER: S-EPMC9238510 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature