Impact of Maternal-Fetal Environment on Mortality in Children With Single Ventricle Heart Disease.

ABSTRACT: BACKGROUND Children with single ventricle heart disease have significant morbidity and mortality. The maternal-fetal environment (MFE) may adversely impact outcomes after neonatal cardiac surgery. We hypothesized that impaired MFE would be associated with an increased risk of death after stage 1 Norwood reconstruction. METHODS AND RESULTS We performed a retrospective cohort study of children with hypoplastic left heart syndrome (and anatomic variants) who underwent stage 1 Norwood reconstruction between 2008 and 2018. Impaired MFE was defined as maternal gestational hypertension, preeclampsia, gestational diabetes, and/or smoking during pregnancy. Cox proportional hazards regression models were used to investigate the association between impaired MFE and death while adjusting for confounde

SUBMITTER: Savla JJ 

PROVIDER: S-EPMC9238520 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature