Cardiorenal Effects of Long-Term Phosphodiesterase V Inhibition in Pre-Heart Failure.

ABSTRACT: Background Phosphodiesterase V (PDEV) is upregulated in heart failure, leading to increased degradation of cGMP and impaired natriuresis. PDEV inhibition improves the renal response to B-type natriuretic peptide in animal models. We tested the hypothesis that long-term PDEV inhibition would improve renal function and cardiorenal response after short-term volume load in subjects with pre-heart failure. Methods and Results A total of 20 subjects with pre-heart failure (defined as an ejection fraction ≤45% without previous diagnosis of heart failure) and renal impairment were randomized in a 2:1 manner to tadalafil or placebo. Baseline echocardiography and renal clearance study were performed, followed by a short-term saline load and repeated echocardiography and renal clearance study. Subjec

SUBMITTER: Hubers SA 

PROVIDER: S-EPMC9238526 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature