Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study.

ABSTRACT: Background Vascular function is compromised in Alzheimer disease (AD) years before amyloid and tau pathology are detected and a substantial body of work shows abnormal platelet activation states in patients with AD. The aim of our study was to investigate whether platelet function in middle age is independently associated with future risk of AD. Methods and Results We examined associations of baseline platelet function with incident dementia risk in the community-based FHS (Framingham Heart Study) longitudinal cohorts. The association between platelet function and risk of dementia was evaluated using the cumulative incidence function and inverse probability weighted Cox proportional cause-specific hazards regression models, with adjustment for demographic and clinical covariates. Platelet

SUBMITTER: Ramos-Cejudo J 

PROVIDER: S-EPMC9238609 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature