A nested case-control study of serum polychlorinated biphenyls and papillary thyroid cancer risk among U.S. military service members.

ABSTRACT:

Background and objectives

Although polychlorinated biphenyls (PCBs) were banned decades ago, populations are continuously exposed to PCBs due to their persistence and bioaccumulation/biomagnification in the environment. Results from limited epidemiologic studies linking PCBs to thyroid cancer have been inconclusive. This study aimed to investigate the association between individual PCBs and PCB mixture and papillary thyroid cancer (PTC), the most common thyroid cancer histologic subtype.

Methods

We carried out a nested case-control study including 742 histologically confirmed PTC cases diagnosed in 2000-2013 and 742 individually matched controls among U.S. military service members. Pre-diagnostic serum samples that were collected on average nine years before PTC diagnosis we

SUBMITTER: Zhuo H 

PROVIDER: S-EPMC9238631 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature