Low-Density Lipoprotein Cholesterol Attributable Cardiovascular Disease Risk Is Sex Specific.

ABSTRACT: Background Epidemiological studies show that women are generally at lower risk for cardiovascular disease than men. Here, we investigated the sex-specific differential effect of genetically increased low-density lipoprotein cholesterol (LDL-C) on cardiovascular disease (CVD) and other lipid-associated diseases. Methods and Results This is a 2-sample Mendelian randomization study that uses individual participant data from 425 043 participants from the UK Biobank, including 229 279 female participants. An 80-variant LDL-C weighted genetic score was generated. Linear and logistic regression models with interactions were used to identify differences between sex-specific LDL-C effects on lipids, carotid-intima media thickness, and multiple cardiovascular outcomes such as CVD, ischemic heart dis

SUBMITTER: Cupido AJ 

PROVIDER: S-EPMC9238661 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature