Centromere Interactions Promote the Maintenance of the Multipartite Genome in Agrobacterium tumefaciens.

ABSTRACT: Many pathogens or symbionts of animals and plants contain multiple replicons, a configuration called a multipartite genome. Multipartite genomes enable those species to replicate their genomes faster and better adapt to new niches. Despite their prevalence, the mechanisms by which multipartite genomes are stably maintained are poorly understood. Agrobacterium tumefaciens is a plant pathogen that contains four replicons: a circular chromosome (Ch1), a linear chromosome (Ch2), and two large plasmids. Recent work indicates that their replication origins are clustered at the cell poles in a manner that depends on their ParB family centromeric proteins: ParB1 for Ch1 and individual RepB paralogs for Ch2 and the plasmids. However, understanding of these interactions and how they contribute to ge

SUBMITTER: Ren Z 

PROVIDER: S-EPMC9239152 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature