A Polymorphism in the Epstein-Barr Virus EBER2 Noncoding RNA Drives <i>In Vivo</i> Expansion of Latently Infected B Cells.

ABSTRACT: The oncogenic gammaherpesviruses, including human Epstein-Barr virus (EBV), human Kaposi's sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 (MHV68, γHV68, MuHV-4), are associated with numerous malignancies, including B cell lymphomas and nasopharyngeal carcinoma. These viruses employ numerous molecular strategies to colonize the host, including the expression of noncoding RNAs (ncRNAs). As the first viral ncRNAs identified, EBV-encoded RNA 1 and 2 (EBER1 and EBER2, respectively) have been investigated extensively for decades; however, their specific in vivo functions remain largely unknown. In work here, we used chimeric MHV68 viruses in an in vivo complementation system to test whether EBV EBER2 contributes to acute and/or chronic phases of infection. Ex

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9239156 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature