Sulfane Sulfur Posttranslationally Modifies the Global Regulator AdpA to Influence Actinorhodin Production and Morphological Differentiation of Streptomyces coelicolor.

ABSTRACT: The transcription factor AdpA is a key regulator controlling both secondary metabolism and morphological differentiation in Streptomyces. Due to its critical functions, its expression undergoes multilevel regulations at transcriptional, posttranscriptional, and translational levels, yet no posttranslational regulation has been reported. Sulfane sulfur, such as hydro polysulfide (HS_nH, n ≥ 2) and organic polysulfide (RS_nH, n ≥ 2), is common inside microorganisms, but its physiological functions are largely unclear. Here, we discovered that sulfane sulfur posttranslationally modifies AdpA in Streptomyces coelicolor via specifically reacting with Cys⁶² of AdpA to form a persulfide (Cys⁶²-SSH). This modification decreases the aff

SUBMITTER: Lu T 

PROVIDER: S-EPMC9239190 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature