Salmonella Facilitates Iron Acquisition through UMPylation of Ferric Uptake Regulator.

ABSTRACT: Iron limitation is a universal strategy of host immunity during bacterial infection. However, the mechanisms by which pathogens antagonize host nutritional immunity have not been fully elucidated. Here, we identified a requirement for the UMPylator YdiU for this process in Salmonella. The expression of YdiU was dramatically induced by the metal starvation signal. The intracellular iron content was much lower in the ΔydiU strain than in wild-type Salmonella, and the ΔydiU strain exhibited severe growth defect under metal deficiency environments. Genome-wide expression analyses revealed significantly decreased expression of iron uptake genes in ΔydiU strain compared with the wild-type strain. Interestingly, YdiU did not affect the expression level of the major iron uptak

SUBMITTER: Jia H 

PROVIDER: S-EPMC9239237 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature