Status of Humoral and Cellular Immune Responses within 12 Months following CoronaVac Vaccination against COVID-19.

ABSTRACT: Understanding immune memory to COVID-19 vaccines is critical for the design and optimal vaccination schedule for curbing the COVID-19 pandemic. Here, we assessed the status of humoral and cellular immune responses at 1, 3, 6, and 12 months after two-dose CoronaVac vaccination. A total of 150 participants were enrolled, and 136 of them completed the study through the 12-month endpoint. Our results show that, at 1 month after vaccination, both binding and neutralizing antibodies could be detected; the seropositive rate of binding antibodies and seroconversion rate of neutralizing antibodies were 99% and 50%, respectively. From 3 to 12 months, the binding and neutralizing antibodies declined over time. At 12 months, the binding and neutralizing antibodies were still detectable and significant

SUBMITTER: Zhao W 

PROVIDER: S-EPMC9239277 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature