Expression of the GZMB Gene Polymorphism, SNP rs8192917, in 990 Han Chinese Patients with Postoperative Keloids.

ABSTRACT: BACKGROUND A keloid is a pathological scar hyperplasia that is affected by genetic and environmental factors. Although the involvement of cytotoxic granzyme B in keloids has been recognized, there is almost no research on granzyme B (GZMB) gene polymorphisms and keloids. This study aimed to explore the relationship between genetic polymorphisms of GZMB and postsurgical keloid susceptibility in the Han Chinese population. MATERIAL AND METHODS A total of 3078 participants, including 990 patients with postsurgical keloids and 2088 controls without postsurgical keloids, were enrolled. We selected 15 common DNA variants in the GZMB gene for analysis. Associations were analyzed in both single marker-based and haplotype-based methods. The Genotype-Tissue Expression database was used to examine th

SUBMITTER: Wen X 

PROVIDER: S-EPMC9239282 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature